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P Kopecková Selected Research

hydroxypropyl methacrylate

3/2008Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs.
12/2007Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells.
1/2004Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer-doxorubicin conjugates to human colon cancer cells.
7/2001Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates.
7/2001Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions.
7/2001Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates.
7/2001The effects of subcellular localization of N-(2-hydroxypropyl)methacrylamide copolymer-Mce(6) conjugates in a human ovarian carcinoma.
4/2001Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.
1/2001Biodistribution and antitumour efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice.
1/2001The cytoplasmic escape and nuclear accumulation of endocytosed and microinjected HPMA copolymers and a basic kinetic study in Hep G2 cells.
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P Kopecková Research Topics

Disease

13Carcinoma (Carcinomatosis)
12/2007 - 01/2000
4Neoplasms (Cancer)
07/2001 - 04/2000
2Ovarian Neoplasms (Ovarian Cancer)
12/2007 - 07/2001
2Barrett Esophagus (Barrett's Esophagus)
07/2001 - 09/2000
2Necrosis
10/2000 - 04/2000
1Renal Cell Carcinoma (Grawitz Tumor)
03/2008
1Osteoporosis
06/2004
1Rheumatoid Arthritis
06/2004
1Colonic Neoplasms (Colon Cancer)
01/2004
1Ulcerative Colitis
07/2001
1Hepatocellular Carcinoma (Hepatoma)
01/2001
1Colitis
09/2000
1Inflammation (Inflammations)
09/2000

Drug/Important Bio-Agent (IBA)

16hydroxypropyl methacrylateIBA
03/2008 - 01/2000
9Doxorubicin (Adriamycin)FDA LinkGeneric
03/2008 - 01/2000
8N-(2-hydroxypropyl)methacrylamideIBA
03/2008 - 01/2000
4PolymersIBA
06/2004 - 01/2000
4Pharmaceutical PreparationsIBA
07/2001 - 09/2000
3meso-chlorin e(6) monoethylene diamineIBA
03/2008 - 11/2000
2Monoclonal AntibodiesIBA
07/2001 - 07/2001
2AntigensIBA
07/2001 - 07/2001
1ThiophenesIBA
03/2008
1Cysteine Proteases (Cysteine Protease)IBA
06/2004
1Cathepsin KIBA
06/2004
1Proteins (Proteins, Gene)FDA Link
01/2004
1RNA (Ribonucleic Acid)IBA
01/2004
1LigandsIBA
01/2004
1Galectin 3 (LGALS3)IBA
01/2004
1CarbohydratesIBA
01/2004
1SugarsIBA
01/2004
1geldanamycinIBA
08/2001
1Immunoglobulin Fab FragmentsIBA
07/2001
1AgglutininsIBA
07/2001
1Wheat Germ AgglutininsIBA
07/2001
1Cyclosporine (Ciclosporin)FDA LinkGeneric
07/2001
1Peanut AgglutininIBA
07/2001
1CaspasesIBA
04/2001
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
11/2000
1Fluorescein-5-isothiocyanate (FITC)IBA
10/2000
1Annexin A5IBA
10/2000
1Propidium (Propidium Iodide)IBA
10/2000
1Thomsen-Friedenreich antigenIBA
09/2000
1LectinsIBA
09/2000
1Caspase 9IBA
04/2000

Therapy/Procedure

2Photochemotherapy (Photodynamic Therapy)
07/2001 - 07/2001
2Therapeutics
07/2001 - 07/2000
1Dye Lasers
07/2001
1Combination Drug Therapy (Combination Chemotherapy)
07/2001
1Drug Therapy (Chemotherapy)
07/2001